p53 mutations as fingerprints of environmental carcinogens
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p 53 mutations as fingerprints of environmental carcinogens *
Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental carcinogens, which also act as DNAdamaging agents. This is probably why p53 mutations are frequent in cancers linked to environmental carcinogens. Moreover, these carcinogens ...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 2000
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac200072060995